Evaluation of a candidate breast cancer associated SNP in ERCC4 as a risk modifier in BRCA1 and BRCA2 mutation carriers. Results from the Consortium of Investigators of Modifiers of BRCA1/BRCA2 (CIMBA)
Identifieur interne : 007C17 ( Main/Exploration ); précédent : 007C16; suivant : 007C18Evaluation of a candidate breast cancer associated SNP in ERCC4 as a risk modifier in BRCA1 and BRCA2 mutation carriers. Results from the Consortium of Investigators of Modifiers of BRCA1/BRCA2 (CIMBA)
Auteurs : A. Osorio [Espagne] ; R L Milne [Espagne] ; G. Pita [Espagne] ; P. Peterlongo [Italie] ; T. Heikkinen [Finlande] ; J. Simard ; G. Chenevix-Trench [Australie] ; A B Spurdle [Australie] ; J. Beesley [Australie] ; X. Chen [Australie] ; S. Healey [Australie] ; S L Neuhausen [États-Unis] ; Y C Ding [États-Unis] ; F J Couch [États-Unis] ; X. Wang [États-Unis] ; N. Lindor [États-Unis] ; S. Manoukian [Italie] ; M. Barile [Italie] ; A. Viel [Italie] ; L. Tizzoni [Italie] ; C I Szabo [États-Unis] ; L. Foretova [République tchèque] ; M. Zikan [République tchèque] ; K. Claes [Belgique] ; M H Greene [États-Unis] ; P. Mai [États-Unis] ; G. Rennert [Israël] ; F. Lejbkowicz [Israël] ; O. Barnett-Griness [Israël] ; I L Andrulis [Canada] ; H. Ozcelik [Canada] ; N. Weerasooriya ; A-M Gerdes [Danemark] ; M. Thomassen [Danemark] ; D G Cruger [Danemark] ; M A Caligo [Italie] ; E. Friedman [Israël] ; B. Kaufman [Israël] ; Y. Laitman ; S. Cohen ; T. Kontorovich ; R. Gershoni-Baruch [Israël] ; E. Dagan [Israël] ; H. Jernström [Suède] ; M S Askmalm [Suède] ; B. Arver [Suède] ; B. Malmer [Suède] ; S M Domchek ; K L Nathanson ; J. Brunet ; T. Ram N Y Cajal [Espagne] ; D. Yannoukakos ; U. Hamann [Allemagne] ; F B L. Hogervorst [États-Unis] ; S. Verhoef [États-Unis] ; Eb G Mez García [États-Unis] ; J T Wijnen [États-Unis] ; A. Van Den Ouweland [États-Unis] ; D F Easton [Royaume-Uni] ; S. Peock [Royaume-Uni] ; M. Cook [Royaume-Uni] ; C T Oliver [Royaume-Uni] ; D. Frost [Royaume-Uni] ; C. Luccarini [Royaume-Uni] ; D G Evans [Royaume-Uni] ; F. Lalloo [Royaume-Uni] ; R. Eeles [Royaume-Uni] ; G. Pichert [Royaume-Uni] ; J. Cook [Royaume-Uni] ; S. Hodgson [Royaume-Uni] ; P J Morrison [Royaume-Uni] ; F. Douglas [Royaume-Uni] ; A K Godwin [États-Unis] ; O M Sinilnikova [France] ; L. Barjhoux [France] ; D. Stoppa-Lyonnet [France] ; V. Moncoutier [France] ; S. Giraud [France] ; C. Cassini [France] ; L. Olivier-Faivre [France] ; F. Révillion [France] ; J-P Peyrat [France] ; D. Muller [France] ; J-P Fricker [France] ; H T Lynch [États-Unis] ; E M John [États-Unis] ; S. Buys [États-Unis] ; M. Daly [États-Unis] ; J L Hopper [Australie] ; M B Terry [États-Unis] ; A. Miron [États-Unis] ; Y. Yassin [États-Unis] ; D. Goldgar [États-Unis] ; C F Singer [Autriche] ; D. Gschwantler-Kaulich [Autriche] ; G. Pfeiler [Autriche] ; A-C Spiess [Autriche] ; Thomas V O. Hansen [Danemark] ; O T Johannsson [Islande] ; T. Kirchhoff [États-Unis] ; K. Offit [États-Unis] ; K. Kosarin [États-Unis] ; M. Piedmonte [États-Unis] ; G C Rodriguez [États-Unis] ; K. Wakeley [États-Unis] ; J F Boggess [États-Unis] ; J. Basil [États-Unis] ; P E Schwartz [États-Unis] ; S V Blank [États-Unis] ; A E Toland ; M. Montagna [Italie] ; C. Casella [Italie] ; E N Imyanitov [Russie] ; A. Allavena [Italie] ; R K Schmutzler [Allemagne] ; B. Versmold [Allemagne] ; C. Engel [Allemagne] ; A. Meindl [Allemagne] ; N. Ditsch [Allemagne] ; N. Arnold [Allemagne] ; D. Niederacher [Allemagne] ; H. Dei Ler [Allemagne] ; B. Fiebig [Allemagne] ; R. Varon-Mateeva [Allemagne] ; D. Schaefer [Allemagne] ; U G Froster [Allemagne] ; T. Caldes [Espagne] ; M. De La Hoya [Espagne] ; L. Mcguffog [Royaume-Uni] ; A C Antoniou [Royaume-Uni] ; H. Nevanlinna [Finlande] ; P. Radice [Italie] ; J. Benítez [Espagne]Source :
- British Journal of Cancer [ 0007-0920 ] ; 2009.
Abstract
In this study we aimed to evaluate the role of a SNP in intron 1 of the
We have genotyped rs744154 in 9408
We found no evidence of association with breast cancer risk for
This SNP is not a significant modifier of breast cancer risk for mutation carriers, though weak associations cannot be ruled out.
Url:
DOI: 10.1038/sj.bjc.6605416
PubMed: 19920816
PubMed Central: 2795432
Affiliations:
- Allemagne, Australie, Autriche, Belgique, Canada, Danemark, Espagne, Finlande, France, Islande, Israël, Italie, Royaume-Uni, Russie, République tchèque, Suède, États-Unis
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000029
- to stream Pmc, to step Curation: 000029
- to stream Pmc, to step Checkpoint: 002809
- to stream Ncbi, to step Merge: 000671
- to stream Ncbi, to step Curation: 000671
- to stream Ncbi, to step Checkpoint: 000671
- to stream Main, to step Merge: 008291
- to stream Main, to step Curation: 007C17
Le document en format XML
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Osorio</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Human Genetics Group, Spanish National Cancer Research Centre</institution> Madrid,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Milne, R L" sort="Milne, R L" uniqKey="Milne R" first="R L" last="Milne">R L Milne</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Centre</institution> Madrid,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Pita, G" sort="Pita, G" uniqKey="Pita G" first="G" last="Pita">G. Pita</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Genotyping Unit, Human Cancer Genetics Programme, Spanish National Cancer Research Centre</institution> Madrid,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Peterlongo, P" sort="Peterlongo, P" uniqKey="Peterlongo P" first="P" last="Peterlongo">P. 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Wang</name><affiliation wicri:level="1"><nlm:aff id="aff11"><institution>Department of Laboratory Medicine and Pathology, Mayo Clinic</institution> Rochester, MN,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lindor, N" sort="Lindor, N" uniqKey="Lindor N" first="N" last="Lindor">N. Lindor</name><affiliation wicri:level="1"><nlm:aff id="aff13"><institution>Department of Medical Genetics, Mayo Clinic</institution> Rochester, MN,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Manoukian, S" sort="Manoukian, S" uniqKey="Manoukian S" first="S" last="Manoukian">S. Manoukian</name><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Fondazione IRCCS Istituto Nazionale Tumori</institution> Milan,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Barile, M" sort="Barile, M" uniqKey="Barile M" first="M" last="Barile">M. Barile</name><affiliation wicri:level="1"><nlm:aff id="aff14"><institution>Istituto Europeo di Oncologia</institution> Milan,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Viel, A" sort="Viel, A" uniqKey="Viel A" first="A" last="Viel">A. Viel</name><affiliation wicri:level="1"><nlm:aff id="aff15"><institution>Centro di Riferimento Oncologico, IRCCS</institution> Aviano, PN,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tizzoni, L" sort="Tizzoni, L" uniqKey="Tizzoni L" first="L" last="Tizzoni">L. Tizzoni</name><affiliation wicri:level="1"><nlm:aff id="aff5"><institution>Fondazione Istituto FIRC di Oncologia Molecolare</institution> Milan,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff16"><institution>Cogentech, Consortium for Genomic Technologies</institution> Milan,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Szabo, C I" sort="Szabo, C I" uniqKey="Szabo C" first="C I" last="Szabo">C I Szabo</name><affiliation wicri:level="1"><nlm:aff id="aff17"><institution>Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine</institution> Rochester, MN,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Foretova, L" sort="Foretova, L" uniqKey="Foretova L" first="L" last="Foretova">L. Foretova</name><affiliation wicri:level="1"><nlm:aff id="aff18"><institution>Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute</institution> Brno,<country>Czech Republic</country></nlm:aff><country xml:lang="fr">République tchèque</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zikan, M" sort="Zikan, M" uniqKey="Zikan M" first="M" last="Zikan">M. Zikan</name><affiliation wicri:level="1"><nlm:aff id="aff19"><institution>Department of Biochemistry and Experimental Oncology, First Faculty of Medicine, Charles University</institution> Prague,<country>Czech Republic</country></nlm:aff><country xml:lang="fr">République tchèque</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Claes, K" sort="Claes, K" uniqKey="Claes K" first="K" last="Claes">K. Claes</name><affiliation wicri:level="1"><nlm:aff id="aff20"><institution>Center for Medical Genetics, Ghent University Hospital</institution> Ghent,<country>Belgium</country></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Greene, M H" sort="Greene, M H" uniqKey="Greene M" first="M H" last="Greene">M H Greene</name><affiliation wicri:level="1"><nlm:aff id="aff21"><institution>Clinical Genetics Branch, National Cancer Institute</institution> Rockville, MD,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mai, P" sort="Mai, P" uniqKey="Mai P" first="P" last="Mai">P. Mai</name><affiliation wicri:level="1"><nlm:aff id="aff21"><institution>Clinical Genetics Branch, National Cancer Institute</institution> Rockville, MD,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rennert, G" sort="Rennert, G" uniqKey="Rennert G" first="G" last="Rennert">G. Rennert</name><affiliation wicri:level="1"><nlm:aff id="aff22"><institution>CHS National Cancer Control Center at Carmel Medical Center and Technion Faculty of Medicine</institution> Haifa,<country>Israel</country></nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lejbkowicz, F" sort="Lejbkowicz, F" uniqKey="Lejbkowicz F" first="F" last="Lejbkowicz">F. Lejbkowicz</name><affiliation wicri:level="1"><nlm:aff id="aff22"><institution>CHS National Cancer Control Center at Carmel Medical Center and Technion Faculty of Medicine</institution> Haifa,<country>Israel</country></nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Barnett Griness, O" sort="Barnett Griness, O" uniqKey="Barnett Griness O" first="O" last="Barnett-Griness">O. Barnett-Griness</name><affiliation wicri:level="1"><nlm:aff id="aff22"><institution>CHS National Cancer Control Center at Carmel Medical Center and Technion Faculty of Medicine</institution> Haifa,<country>Israel</country></nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Andrulis, I L" sort="Andrulis, I L" uniqKey="Andrulis I" first="I L" last="Andrulis">I L Andrulis</name><affiliation><nlm:aff id="aff23"><institution>Ontario Cancer Genetics Network (OCGN), Cancer Care Ontario, Toronto, ON, Canada</institution></nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="aff24"><institution>Fred A. Litwin Center for Cancer Genetics, Samuel Lunenfeld Research Institute</institution> Mount Sinai, Toronto, ON, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea> Mount Sinai, Toronto, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author><author><name sortKey="Ozcelik, H" sort="Ozcelik, H" uniqKey="Ozcelik H" first="H" last="Ozcelik">H. Ozcelik</name><affiliation wicri:level="1"><nlm:aff id="aff24"><institution>Fred A. Litwin Center for Cancer Genetics, Samuel Lunenfeld Research Institute</institution> Mount Sinai, Toronto, ON, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea> Mount Sinai, Toronto, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author><author><name sortKey="Weerasooriya, N" sort="Weerasooriya, N" uniqKey="Weerasooriya N" first="N" last="Weerasooriya">N. Weerasooriya</name><affiliation><nlm:aff id="aff23"><institution>Ontario Cancer Genetics Network (OCGN), Cancer Care Ontario, Toronto, ON, Canada</institution></nlm:aff></affiliation></author><author><name sortKey="Gerdes, A M" sort="Gerdes, A M" uniqKey="Gerdes A" first="A-M" last="Gerdes">A-M Gerdes</name><affiliation wicri:level="1"><nlm:aff id="aff25"><institution>Clinical Genetics BFG, Odense University Hospital</institution> Odense,<country>Denmark</country></nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Thomassen, M" sort="Thomassen, M" uniqKey="Thomassen M" first="M" last="Thomassen">M. Thomassen</name><affiliation wicri:level="1"><nlm:aff id="aff25"><institution>Clinical Genetics BFG, Odense University Hospital</institution> Odense,<country>Denmark</country></nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cruger, D G" sort="Cruger, D G" uniqKey="Cruger D" first="D G" last="Cruger">D G Cruger</name><affiliation wicri:level="1"><nlm:aff id="aff26"><institution>Department of Clinical Genetics, Vejle Hospital</institution><country>Vijle, Denmark</country></nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Caligo, M A" sort="Caligo, M A" uniqKey="Caligo M" first="M A" last="Caligo">M A Caligo</name><affiliation wicri:level="1"><nlm:aff id="aff27"><institution>Division of Pathology, Department of Oncology, University and University Hospital of Pisa</institution> Pisa,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Friedman, E" sort="Friedman, E" uniqKey="Friedman E" first="E" last="Friedman">E. Friedman</name><affiliation><nlm:aff id="aff28"><institution>Sheba Medical Centre (SMC), Tel Hashomer, Israel</institution></nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="aff29"><institution>The Sackler School of Medicine, Tel-Aviv University</institution> Tel-Aviv,<country>Israel</country></nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kaufman, B" sort="Kaufman, B" uniqKey="Kaufman B" first="B" last="Kaufman">B. Kaufman</name><affiliation><nlm:aff id="aff28"><institution>Sheba Medical Centre (SMC), Tel Hashomer, Israel</institution></nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="aff29"><institution>The Sackler School of Medicine, Tel-Aviv University</institution> Tel-Aviv,<country>Israel</country></nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Laitman, Y" sort="Laitman, Y" uniqKey="Laitman Y" first="Y" last="Laitman">Y. Laitman</name><affiliation><nlm:aff id="aff28"><institution>Sheba Medical Centre (SMC), Tel Hashomer, Israel</institution></nlm:aff></affiliation></author><author><name sortKey="Cohen, S" sort="Cohen, S" uniqKey="Cohen S" first="S" last="Cohen">S. Cohen</name><affiliation><nlm:aff id="aff28"><institution>Sheba Medical Centre (SMC), Tel Hashomer, Israel</institution></nlm:aff></affiliation></author><author><name sortKey="Kontorovich, T" sort="Kontorovich, T" uniqKey="Kontorovich T" first="T" last="Kontorovich">T. Kontorovich</name><affiliation><nlm:aff id="aff28"><institution>Sheba Medical Centre (SMC), Tel Hashomer, Israel</institution></nlm:aff></affiliation></author><author><name sortKey="Gershoni Baruch, R" sort="Gershoni Baruch, R" uniqKey="Gershoni Baruch R" first="R" last="Gershoni-Baruch">R. Gershoni-Baruch</name><affiliation wicri:level="1"><nlm:aff id="aff30"><institution>Rambam Medical Centre</institution> Haifa,<country>Israel</country></nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Dagan, E" sort="Dagan, E" uniqKey="Dagan E" first="E" last="Dagan">E. Dagan</name><affiliation wicri:level="1"><nlm:aff id="aff31"><institution>Department of Nursing, Faculty of Social Welfare and Health Sciences, University of Haifa</institution><country>Haifa, Israel</country></nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea></wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff32"><institution>Rambam Health Care Campus, Institute of Human Genetics</institution> Haifa,<country>Israel</country></nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Jernstrom, H" sort="Jernstrom, H" uniqKey="Jernstrom H" first="H" last="Jernström">H. Jernström</name><affiliation wicri:level="1"><nlm:aff id="aff33"><institution>Department of Oncology, Clinical Sciences, Lund University</institution> Lund,<country>Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Askmalm, M S" sort="Askmalm, M S" uniqKey="Askmalm M" first="M S" last="Askmalm">M S Askmalm</name><affiliation wicri:level="1"><nlm:aff id="aff34"><institution>Department of Oncology, University Hospital</institution> Linköping, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea> Linköping</wicri:regionArea></affiliation></author><author><name sortKey="Arver, B" sort="Arver, B" uniqKey="Arver B" first="B" last="Arver">B. Arver</name><affiliation wicri:level="1"><nlm:aff id="aff35"><institution>Department of Oncology, Karolinska University Hospital</institution> Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea> Stockholm</wicri:regionArea></affiliation></author><author><name sortKey="Malmer, B" sort="Malmer, B" uniqKey="Malmer B" first="B" last="Malmer">B. Malmer</name><affiliation wicri:level="1"><nlm:aff id="aff36"><institution>Department of Radiation Sciences, Oncology, Umeå University</institution> Umeå, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea> Umeå</wicri:regionArea></affiliation></author><author><name sortKey="Domchek, S M" sort="Domchek, S M" uniqKey="Domchek S" first="S M" last="Domchek">S M Domchek</name><affiliation><nlm:aff id="aff38"><institution>Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA</institution></nlm:aff></affiliation></author><author><name sortKey="Nathanson, K L" sort="Nathanson, K L" uniqKey="Nathanson K" first="K L" last="Nathanson">K L Nathanson</name><affiliation><nlm:aff id="aff38"><institution>Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA</institution></nlm:aff></affiliation></author><author><name sortKey="Brunet, J" sort="Brunet, J" uniqKey="Brunet J" first="J" last="Brunet">J. Brunet</name><affiliation><nlm:aff id="aff39"><institution>Programa de Consejo Genético en Cáncer, Instituto Catalán de Oncología, Hospital Dr Josep Trueta-IdiBGi, Gerona, Spain</institution></nlm:aff></affiliation></author><author><name sortKey="Ram N Y Cajal, T" sort="Ram N Y Cajal, T" uniqKey="Ram N Y Cajal T" first="T" last="Ram N Y Cajal">T. Ram N Y Cajal</name><affiliation wicri:level="1"><nlm:aff id="aff40"><institution>Servicio de Oncología Médica del Hospital de la Santa Creu i Sant Pau</institution> Barcelona,<country>España</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Yannoukakos, D" sort="Yannoukakos, D" uniqKey="Yannoukakos D" first="D" last="Yannoukakos">D. Yannoukakos</name><affiliation><nlm:aff id="aff41"><institution>IRRP, National Centre for Scientific Research ‘Demokritos', Molecular Diagnostics Laboratory, Athens, Greece</institution></nlm:aff></affiliation></author><author><name sortKey="Hamann, U" sort="Hamann, U" uniqKey="Hamann U" first="U" last="Hamann">U. Hamann</name><affiliation wicri:level="1"><nlm:aff id="aff42"><institution>Molecular Genetics of Breast Cancer, Deutsches Krebsforschungszentrum (DKFZ)</institution> Heidelberg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hogervorst, F B L" sort="Hogervorst, F B L" uniqKey="Hogervorst F" first="F B L" last="Hogervorst">F B L. Hogervorst</name><affiliation wicri:level="1"><nlm:aff id="aff43"><institution>Department of Clinical Molecular Genetics, Family Cancer Clinic, Netherlands Cancer Institute</institution> Amsterdam, NL,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Verhoef, S" sort="Verhoef, S" uniqKey="Verhoef S" first="S" last="Verhoef">S. Verhoef</name><affiliation wicri:level="1"><nlm:aff id="aff43"><institution>Department of Clinical Molecular Genetics, Family Cancer Clinic, Netherlands Cancer Institute</institution> Amsterdam, NL,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Garcia, Eb G Mez" sort="Garcia, Eb G Mez" uniqKey="Garcia E" first="Eb G Mez" last="García">Eb G Mez García</name><affiliation><nlm:aff id="aff44"><institution>Department of Genetics and Cell Biology, University Medical Centre, Maastricht, NL</institution></nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="aff45"><institution>Research Institute Growth and Development (GROW)</institution> Maastricht, NL,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wijnen, J T" sort="Wijnen, J T" uniqKey="Wijnen J" first="J T" last="Wijnen">J T Wijnen</name><affiliation wicri:level="1"><nlm:aff id="aff46"><institution>Department Clinical Molecular Genetics, Leiden University Medical Center</institution> Leiden, NL,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff47"><institution>Department of Human Genetic, Leiden University Medical Center</institution> Leiden, NL,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Van Den Ouweland, A" sort="Van Den Ouweland, A" uniqKey="Van Den Ouweland A" first="A" last="Van Den Ouweland">A. Van Den Ouweland</name><affiliation wicri:level="1"><nlm:aff id="aff48"><institution>Department of Molecular Genetics, Erasmus University Medical Center</institution> Rotterdam, NL,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Easton, D F" sort="Easton, D F" uniqKey="Easton D" first="D F" last="Easton">D F Easton</name><affiliation wicri:level="1"><nlm:aff id="aff49"><institution>Department of Public Health and Primary Care, Cancer Research UK Genetic Epidemiology Unit, University of Cambridge</institution> Cambridge,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Peock, S" sort="Peock, S" uniqKey="Peock S" first="S" last="Peock">S. Peock</name><affiliation wicri:level="1"><nlm:aff id="aff49"><institution>Department of Public Health and Primary Care, Cancer Research UK Genetic Epidemiology Unit, University of Cambridge</institution> Cambridge,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cook, M" sort="Cook, M" uniqKey="Cook M" first="M" last="Cook">M. Cook</name><affiliation wicri:level="1"><nlm:aff id="aff49"><institution>Department of Public Health and Primary Care, Cancer Research UK Genetic Epidemiology Unit, University of Cambridge</institution> Cambridge,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Oliver, C T" sort="Oliver, C T" uniqKey="Oliver C" first="C T" last="Oliver">C T Oliver</name><affiliation wicri:level="1"><nlm:aff id="aff49"><institution>Department of Public Health and Primary Care, Cancer Research UK Genetic Epidemiology Unit, University of Cambridge</institution> Cambridge,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Frost, D" sort="Frost, D" uniqKey="Frost D" first="D" last="Frost">D. Frost</name><affiliation wicri:level="1"><nlm:aff id="aff49"><institution>Department of Public Health and Primary Care, Cancer Research UK Genetic Epidemiology Unit, University of Cambridge</institution> Cambridge,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Luccarini, C" sort="Luccarini, C" uniqKey="Luccarini C" first="C" last="Luccarini">C. Luccarini</name><affiliation wicri:level="1"><nlm:aff id="aff50"><institution>Department of Oncology, University of Cambridge</institution> Cambridge,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Evans, D G" sort="Evans, D G" uniqKey="Evans D" first="D G" last="Evans">D G Evans</name><affiliation wicri:level="1"><nlm:aff id="aff51"><institution>Academic Unit of Medical Genetics and Regional Genetics Service, St Mary's Hospital</institution> Manchester,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lalloo, F" sort="Lalloo, F" uniqKey="Lalloo F" first="F" last="Lalloo">F. Lalloo</name><affiliation wicri:level="1"><nlm:aff id="aff51"><institution>Academic Unit of Medical Genetics and Regional Genetics Service, St Mary's Hospital</institution> Manchester,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Eeles, R" sort="Eeles, R" uniqKey="Eeles R" first="R" last="Eeles">R. Eeles</name><affiliation wicri:level="1"><nlm:aff id="aff52"><institution>Translational Cancer Genetics Team, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust</institution><country>London, UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Pichert, G" sort="Pichert, G" uniqKey="Pichert G" first="G" last="Pichert">G. Pichert</name><affiliation wicri:level="1"><nlm:aff id="aff53"><institution>Clinical Genetics, Guy's Hospital</institution> London,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cook, J" sort="Cook, J" uniqKey="Cook J" first="J" last="Cook">J. Cook</name><affiliation wicri:level="1"><nlm:aff id="aff54"><institution>Sheffield Clinical Genetics Service, Sheffield Children's Hospital</institution> Sheffield,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hodgson, S" sort="Hodgson, S" uniqKey="Hodgson S" first="S" last="Hodgson">S. Hodgson</name><affiliation wicri:level="1"><nlm:aff id="aff55"><institution>Department of Cancer Genetics, St Georges Hospital, University of London</institution> London,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Morrison, P J" sort="Morrison, P J" uniqKey="Morrison P" first="P J" last="Morrison">P J Morrison</name><affiliation wicri:level="1"><nlm:aff id="aff56"><institution>Northern Ireland Regional Genetics Centre, Belfast City Hospital</institution> Belfast,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Douglas, F" sort="Douglas, F" uniqKey="Douglas F" first="F" last="Douglas">F. Douglas</name><affiliation wicri:level="1"><nlm:aff id="aff57"><institution>Institute of Human Genetics, Centre for Life, Newcastle Upon Tyne Hospitals NHS Trust</institution> Newcastle upon Tyne,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Godwin, A K" sort="Godwin, A K" uniqKey="Godwin A" first="A K" last="Godwin">A K Godwin</name><affiliation wicri:level="1"><nlm:aff id="aff58"><institution>Fox Chase Cancer Center</institution> Philadelphia, PA,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sinilnikova, O M" sort="Sinilnikova, O M" uniqKey="Sinilnikova O" first="O M" last="Sinilnikova">O M Sinilnikova</name><affiliation wicri:level="1"><nlm:aff id="aff59"><institution>Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Hospices Civils de Lyon/Centre Léon Bérard</institution> Lyon,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff60"><institution>Laboratoire de Génétique Moléculaire, Signalisation et Cancer, UMR5201 CNRS, Université de Lyon</institution> Lyon,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Barjhoux, L" sort="Barjhoux, L" uniqKey="Barjhoux L" first="L" last="Barjhoux">L. Barjhoux</name><affiliation wicri:level="1"><nlm:aff id="aff59"><institution>Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Hospices Civils de Lyon/Centre Léon Bérard</institution> Lyon,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff60"><institution>Laboratoire de Génétique Moléculaire, Signalisation et Cancer, UMR5201 CNRS, Université de Lyon</institution> Lyon,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Stoppa Lyonnet, D" sort="Stoppa Lyonnet, D" uniqKey="Stoppa Lyonnet D" first="D" last="Stoppa-Lyonnet">D. Stoppa-Lyonnet</name><affiliation wicri:level="1"><nlm:aff id="aff61"><institution>INSERM U509, Service de Génétique Oncologique, Institut Curie, Université Paris-Descartes</institution> Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Moncoutier, V" sort="Moncoutier, V" uniqKey="Moncoutier V" first="V" last="Moncoutier">V. Moncoutier</name><affiliation wicri:level="1"><nlm:aff id="aff61"><institution>INSERM U509, Service de Génétique Oncologique, Institut Curie, Université Paris-Descartes</institution> Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Giraud, S" sort="Giraud, S" uniqKey="Giraud S" first="S" last="Giraud">S. Giraud</name><affiliation wicri:level="1"><nlm:aff id="aff59"><institution>Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Hospices Civils de Lyon/Centre Léon Bérard</institution> Lyon,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cassini, C" sort="Cassini, C" uniqKey="Cassini C" first="C" last="Cassini">C. Cassini</name><affiliation wicri:level="1"><nlm:aff id="aff62"><institution>Centre de Génétique</institution> Dijon,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff63"><institution>CLCC Georges François Leclerc</institution> Dijon,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Olivier Faivre, L" sort="Olivier Faivre, L" uniqKey="Olivier Faivre L" first="L" last="Olivier-Faivre">L. Olivier-Faivre</name><affiliation wicri:level="1"><nlm:aff id="aff62"><institution>Centre de Génétique</institution> Dijon,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff63"><institution>CLCC Georges François Leclerc</institution> Dijon,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Revillion, F" sort="Revillion, F" uniqKey="Revillion F" first="F" last="Révillion">F. Révillion</name><affiliation wicri:level="1"><nlm:aff id="aff64"><institution>Human Molecular Oncology Laboratory, Centre Oscar Lambret</institution> Lille,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Peyrat, J P" sort="Peyrat, J P" uniqKey="Peyrat J" first="J-P" last="Peyrat">J-P Peyrat</name><affiliation wicri:level="1"><nlm:aff id="aff64"><institution>Human Molecular Oncology Laboratory, Centre Oscar Lambret</institution> Lille,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Muller, D" sort="Muller, D" uniqKey="Muller D" first="D" last="Muller">D. Muller</name><affiliation wicri:level="1"><nlm:aff id="aff65"><institution>Unité d'Oncogénétique, CLCC Paul Strauss</institution> Strasbourg,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Fricker, J P" sort="Fricker, J P" uniqKey="Fricker J" first="J-P" last="Fricker">J-P Fricker</name><affiliation wicri:level="1"><nlm:aff id="aff65"><institution>Unité d'Oncogénétique, CLCC Paul Strauss</institution> Strasbourg,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lynch, H T" sort="Lynch, H T" uniqKey="Lynch H" first="H T" last="Lynch">H T Lynch</name><affiliation wicri:level="1"><nlm:aff id="aff66"><institution>Department of Preventive Medicine, Creighton University</institution> Omaha, NE,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="John, E M" sort="John, E M" uniqKey="John E" first="E M" last="John">E M John</name><affiliation wicri:level="1"><nlm:aff id="aff67"><institution>Northern California Cancer Center</institution> Fremont, CA,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Buys, S" sort="Buys, S" uniqKey="Buys S" first="S" last="Buys">S. Buys</name><affiliation wicri:level="1"><nlm:aff id="aff68"><institution>Huntsman Cancer Institute</institution> Salt Lake City, UT,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Daly, M" sort="Daly, M" uniqKey="Daly M" first="M" last="Daly">M. Daly</name><affiliation wicri:level="1"><nlm:aff id="aff69"><institution>Fox Chase Cancer Center</institution> Philadelphia, PA,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hopper, J L" sort="Hopper, J L" uniqKey="Hopper J" first="J L" last="Hopper">J L Hopper</name><affiliation wicri:level="1"><nlm:aff id="aff70"><institution>University of Melbourne</institution> Melbourne,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Terry, M B" sort="Terry, M B" uniqKey="Terry M" first="M B" last="Terry">M B Terry</name><affiliation wicri:level="1"><nlm:aff id="aff71"><institution>Columbia University New York</institution> NY,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Miron, A" sort="Miron, A" uniqKey="Miron A" first="A" last="Miron">A. Miron</name><affiliation wicri:level="1"><nlm:aff id="aff72"><institution>Dana Farber Cancer Institute</institution> Boston, MA,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Yassin, Y" sort="Yassin, Y" uniqKey="Yassin Y" first="Y" last="Yassin">Y. Yassin</name><affiliation wicri:level="1"><nlm:aff id="aff72"><institution>Dana Farber Cancer Institute</institution> Boston, MA,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Goldgar, D" sort="Goldgar, D" uniqKey="Goldgar D" first="D" last="Goldgar">D. Goldgar</name><affiliation wicri:level="1"><nlm:aff id="aff73"><institution>Department of Dermatology, University of Utah</institution> Salt Lake City, UT,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Singer, C F" sort="Singer, C F" uniqKey="Singer C" first="C F" last="Singer">C F Singer</name><affiliation wicri:level="1"><nlm:aff id="aff74"><institution>Division of Special Gynecology, Department of OB/GYN, Medical University of Vienna</institution> Vienna,<country>Austria</country></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gschwantler Kaulich, D" sort="Gschwantler Kaulich, D" uniqKey="Gschwantler Kaulich D" first="D" last="Gschwantler-Kaulich">D. Gschwantler-Kaulich</name><affiliation wicri:level="1"><nlm:aff id="aff74"><institution>Division of Special Gynecology, Department of OB/GYN, Medical University of Vienna</institution> Vienna,<country>Austria</country></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Pfeiler, G" sort="Pfeiler, G" uniqKey="Pfeiler G" first="G" last="Pfeiler">G. Pfeiler</name><affiliation wicri:level="1"><nlm:aff id="aff74"><institution>Division of Special Gynecology, Department of OB/GYN, Medical University of Vienna</institution> Vienna,<country>Austria</country></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Spiess, A C" sort="Spiess, A C" uniqKey="Spiess A" first="A-C" last="Spiess">A-C Spiess</name><affiliation wicri:level="1"><nlm:aff id="aff74"><institution>Division of Special Gynecology, Department of OB/GYN, Medical University of Vienna</institution> Vienna,<country>Austria</country></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hansen, Thomas V O" sort="Hansen, Thomas V O" uniqKey="Hansen T" first="Thomas V O" last="Hansen">Thomas V O. Hansen</name><affiliation wicri:level="1"><nlm:aff id="aff75"><institution>Department of Biochemistry, Pharmacology, and Genetics, Odense University Hospital</institution><country>Odense, Denmark</country></nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Johannsson, O T" sort="Johannsson, O T" uniqKey="Johannsson O" first="O T" last="Johannsson">O T Johannsson</name><affiliation wicri:level="1"><nlm:aff id="aff76"><institution>Department of Oncology, Landspitali-University Hospital</institution> Reykjavik,<country>Iceland</country> (OThJ)</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kirchhoff, T" sort="Kirchhoff, T" uniqKey="Kirchhoff T" first="T" last="Kirchhoff">T. Kirchhoff</name><affiliation wicri:level="1"><nlm:aff id="aff77"><institution>Department of Medicine, Clinical Genetics Service, Memorial Sloan-Kettering Cancer Center</institution> New York, NY,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Offit, K" sort="Offit, K" uniqKey="Offit K" first="K" last="Offit">K. Offit</name><affiliation wicri:level="1"><nlm:aff id="aff77"><institution>Department of Medicine, Clinical Genetics Service, Memorial Sloan-Kettering Cancer Center</institution> New York, NY,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kosarin, K" sort="Kosarin, K" uniqKey="Kosarin K" first="K" last="Kosarin">K. Kosarin</name><affiliation wicri:level="1"><nlm:aff id="aff77"><institution>Department of Medicine, Clinical Genetics Service, Memorial Sloan-Kettering Cancer Center</institution> New York, NY,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Piedmonte, M" sort="Piedmonte, M" uniqKey="Piedmonte M" first="M" last="Piedmonte">M. Piedmonte</name><affiliation wicri:level="1"><nlm:aff id="aff78"><institution>GOG Statistical and Data Center, Roswell Park Cancer Institute</institution> Buffalo, NY,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rodriguez, G C" sort="Rodriguez, G C" uniqKey="Rodriguez G" first="G C" last="Rodriguez">G C Rodriguez</name><affiliation wicri:level="1"><nlm:aff id="aff79"><institution>NorthShore University Health System, Evanston Northwestern Healthcare</institution> Evanston, IL,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wakeley, K" sort="Wakeley, K" uniqKey="Wakeley K" first="K" last="Wakeley">K. Wakeley</name><affiliation wicri:level="1"><nlm:aff id="aff80"><institution>Tufts University, New England Medical Center</institution> Boston, MA,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Boggess, J F" sort="Boggess, J F" uniqKey="Boggess J" first="J F" last="Boggess">J F Boggess</name><affiliation wicri:level="1"><nlm:aff id="aff81"><institution>University of North Carolina</institution> Chapel Hill, NC,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Basil, J" sort="Basil, J" uniqKey="Basil J" first="J" last="Basil">J. Basil</name><affiliation wicri:level="1"><nlm:aff id="aff82"><institution>St Elizabeth Medical Center</institution> Edgewood, KY,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Schwartz, P E" sort="Schwartz, P E" uniqKey="Schwartz P" first="P E" last="Schwartz">P E Schwartz</name><affiliation wicri:level="1"><nlm:aff id="aff83"><institution>Yale University School of Medicine</institution> New Haven, CT,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Blank, S V" sort="Blank, S V" uniqKey="Blank S" first="S V" last="Blank">S V Blank</name><affiliation wicri:level="1"><nlm:aff id="aff84"><institution>New York University School of Medicine</institution> New York, NY,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Toland, A E" sort="Toland, A E" uniqKey="Toland A" first="A E" last="Toland">A E Toland</name><affiliation><nlm:aff id="aff85"><institution>Division of Human Cancer Genetics, Departments of Internal Medicine and Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, OHIO, USA</institution></nlm:aff></affiliation></author><author><name sortKey="Montagna, M" sort="Montagna, M" uniqKey="Montagna M" first="M" last="Montagna">M. Montagna</name><affiliation wicri:level="1"><nlm:aff id="aff86"><institution>Instituto Oncologico Veneto – IRCCS</institution> Padua,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Casella, C" sort="Casella, C" uniqKey="Casella C" first="C" last="Casella">C. Casella</name><affiliation wicri:level="1"><nlm:aff id="aff87"><institution>Department of Oncology and Surgical Sciences</institution> Padua,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Imyanitov, E N" sort="Imyanitov, E N" uniqKey="Imyanitov E" first="E N" last="Imyanitov">E N Imyanitov</name><affiliation wicri:level="1"><nlm:aff id="aff88"><institution>N.N. Petrov Institute of Oncology</institution> St-Petersburg,<country>Russia</country></nlm:aff><country xml:lang="fr">Russie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Allavena, A" sort="Allavena, A" uniqKey="Allavena A" first="A" last="Allavena">A. Allavena</name><affiliation wicri:level="1"><nlm:aff id="aff89"><institution>Department of Genetics, Biology and Biochemistry, University of Turin</institution> Turin,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Schmutzler, R K" sort="Schmutzler, R K" uniqKey="Schmutzler R" first="R K" last="Schmutzler">R K Schmutzler</name><affiliation wicri:level="1"><nlm:aff id="aff90"><institution>Division of Molecular Gynaeco-Oncology, Department of Obstetrics and Gynaecology, University of Cologne</institution><country>Cologne, Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Versmold, B" sort="Versmold, B" uniqKey="Versmold B" first="B" last="Versmold">B. Versmold</name><affiliation wicri:level="1"><nlm:aff id="aff90"><institution>Division of Molecular Gynaeco-Oncology, Department of Obstetrics and Gynaecology, University of Cologne</institution><country>Cologne, Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Engel, C" sort="Engel, C" uniqKey="Engel C" first="C" last="Engel">C. Engel</name><affiliation wicri:level="1"><nlm:aff id="aff91"><institution>Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig</institution><country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Meindl, A" sort="Meindl, A" uniqKey="Meindl A" first="A" last="Meindl">A. Meindl</name><affiliation wicri:level="1"><nlm:aff id="aff92"><institution>Department of Obstetrics and Gynaecology, Technical University Munich</institution><country>Munich, Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Ditsch, N" sort="Ditsch, N" uniqKey="Ditsch N" first="N" last="Ditsch">N. Ditsch</name><affiliation wicri:level="1"><nlm:aff id="aff93"><institution>Department of Obstetrics and Gynaecology, Ludwig-Maximilian University Munich</institution> Munich,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Arnold, N" sort="Arnold, N" uniqKey="Arnold N" first="N" last="Arnold">N. Arnold</name><affiliation wicri:level="1"><nlm:aff id="aff94"><institution>Department of Obstetrics and Gynaecology, University of Schleswig-Holstein</institution> Campus Kiel,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Niederacher, D" sort="Niederacher, D" uniqKey="Niederacher D" first="D" last="Niederacher">D. Niederacher</name><affiliation wicri:level="1"><nlm:aff id="aff95"><institution>Department of Obstetrics and Gynaecology, Molecular Genetics Laboratory, University of Duesseldorf</institution><country>Dusseldorf, Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Dei Ler, H" sort="Dei Ler, H" uniqKey="Dei Ler H" first="H" last="Dei Ler">H. Dei Ler</name><affiliation wicri:level="1"><nlm:aff id="aff96"><institution>Department of Obstetrics and Gynaecology, University of Ulm</institution> Ulm,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Fiebig, B" sort="Fiebig, B" uniqKey="Fiebig B" first="B" last="Fiebig">B. Fiebig</name><affiliation wicri:level="1"><nlm:aff id="aff97"><institution>University of Regensburg, Institute of Human Genetics</institution> Regensburg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Varon Mateeva, R" sort="Varon Mateeva, R" uniqKey="Varon Mateeva R" first="R" last="Varon-Mateeva">R. Varon-Mateeva</name><affiliation wicri:level="1"><nlm:aff id="aff98"><institution>Institute of Human Genetics, Charité, Humboldt University</institution> Berlin,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Schaefer, D" sort="Schaefer, D" uniqKey="Schaefer D" first="D" last="Schaefer">D. Schaefer</name><affiliation wicri:level="1"><nlm:aff id="aff99"><institution>Institute of Human Genetics, University of Frankfurt</institution> Frankfurt,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Froster, U G" sort="Froster, U G" uniqKey="Froster U" first="U G" last="Froster">U G Froster</name><affiliation wicri:level="1"><nlm:aff id="aff100"><institution>Institute of Human Genetics, University of Leipzig</institution> Leipzig,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Caldes, T" sort="Caldes, T" uniqKey="Caldes T" first="T" last="Caldes">T. Caldes</name><affiliation wicri:level="1"><nlm:aff id="aff101"><institution>Hospital Clínico San Carlos</institution> Madrid,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="De La Hoya, M" sort="De La Hoya, M" uniqKey="De La Hoya M" first="M" last="De La Hoya">M. De La Hoya</name><affiliation wicri:level="1"><nlm:aff id="aff101"><institution>Hospital Clínico San Carlos</institution> Madrid,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mcguffog, L" sort="Mcguffog, L" uniqKey="Mcguffog L" first="L" last="Mcguffog">L. Mcguffog</name><affiliation wicri:level="1"><nlm:aff id="aff49"><institution>Department of Public Health and Primary Care, Cancer Research UK Genetic Epidemiology Unit, University of Cambridge</institution> Cambridge,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Antoniou, A C" sort="Antoniou, A C" uniqKey="Antoniou A" first="A C" last="Antoniou">A C Antoniou</name><affiliation wicri:level="1"><nlm:aff id="aff49"><institution>Department of Public Health and Primary Care, Cancer Research UK Genetic Epidemiology Unit, University of Cambridge</institution> Cambridge,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Nevanlinna, H" sort="Nevanlinna, H" uniqKey="Nevanlinna H" first="H" last="Nevanlinna">H. Nevanlinna</name><affiliation wicri:level="1"><nlm:aff id="aff6"><institution>Department of Obstetrics and Gynaecology, Helsinki University Central Hospital (HUCH)</institution> HelsVinki,<country>Finland</country></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Radice, P" sort="Radice, P" uniqKey="Radice P" first="P" last="Radice">P. Radice</name><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Fondazione IRCCS Istituto Nazionale Tumori</institution> Milan,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff5"><institution>Fondazione Istituto FIRC di Oncologia Molecolare</institution> Milan,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Benitez, J" sort="Benitez, J" uniqKey="Benitez J" first="J" last="Benítez">J. Benítez</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Human Genetics Group, Spanish National Cancer Research Centre</institution> Madrid,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Genotyping Unit, Human Cancer Genetics Programme, Spanish National Cancer Research Centre</institution> Madrid,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">19920816</idno><idno type="pmc">2795432</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2795432</idno><idno type="RBID">PMC:2795432</idno><idno type="doi">10.1038/sj.bjc.6605416</idno><date when="2009">2009</date><idno type="wicri:Area/Pmc/Corpus">000029</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000029</idno><idno type="wicri:Area/Pmc/Curation">000029</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000029</idno><idno type="wicri:Area/Pmc/Checkpoint">002809</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">002809</idno><idno type="wicri:Area/Ncbi/Merge">000671</idno><idno type="wicri:Area/Ncbi/Curation">000671</idno><idno type="wicri:Area/Ncbi/Checkpoint">000671</idno><idno type="wicri:doubleKey">0007-0920:2009:Osorio A:evaluation:of:a</idno><idno type="wicri:Area/Main/Merge">008291</idno><idno type="wicri:Area/Main/Curation">007C17</idno><idno type="wicri:Area/Main/Exploration">007C17</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Evaluation of a candidate breast cancer associated SNP in <italic>ERCC4</italic> as a risk modifier in <italic>BRCA1</italic> and <italic>BRCA2</italic> mutation carriers. Results from the Consortium of Investigators of Modifiers of <italic>BRCA1/BRCA2</italic> (CIMBA)</title><author><name sortKey="Osorio, A" sort="Osorio, A" uniqKey="Osorio A" first="A" last="Osorio">A. Osorio</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Human Genetics Group, Spanish National Cancer Research Centre</institution> Madrid,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Milne, R L" sort="Milne, R L" uniqKey="Milne R" first="R L" last="Milne">R L Milne</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Centre</institution> Madrid,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Pita, G" sort="Pita, G" uniqKey="Pita G" first="G" last="Pita">G. Pita</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Genotyping Unit, Human Cancer Genetics Programme, Spanish National Cancer Research Centre</institution> Madrid,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Peterlongo, P" sort="Peterlongo, P" uniqKey="Peterlongo P" first="P" last="Peterlongo">P. Peterlongo</name><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Fondazione IRCCS Istituto Nazionale Tumori</institution> Milan,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff5"><institution>Fondazione Istituto FIRC di Oncologia Molecolare</institution> Milan,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Heikkinen, T" sort="Heikkinen, T" uniqKey="Heikkinen T" first="T" last="Heikkinen">T. Heikkinen</name><affiliation wicri:level="1"><nlm:aff id="aff6"><institution>Department of Obstetrics and Gynaecology, Helsinki University Central Hospital (HUCH)</institution> HelsVinki,<country>Finland</country></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Simard, J" sort="Simard, J" uniqKey="Simard J" first="J" last="Simard">J. Simard</name><affiliation><nlm:aff id="aff7"><institution>Canada Research Chair in Oncogenetics, Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Québec and Laval University, Québec, Canada</institution></nlm:aff></affiliation></author><author><name sortKey="Chenevix Trench, G" sort="Chenevix Trench, G" uniqKey="Chenevix Trench G" first="G" last="Chenevix-Trench">G. Chenevix-Trench</name><affiliation wicri:level="1"><nlm:aff id="aff8"><institution>Division of Genetics and Population Health, Queensland Institute of Medical Research</institution> Brisbane,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Spurdle, A B" sort="Spurdle, A B" uniqKey="Spurdle A" first="A B" last="Spurdle">A B Spurdle</name><affiliation wicri:level="1"><nlm:aff id="aff8"><institution>Division of Genetics and Population Health, Queensland Institute of Medical Research</institution> Brisbane,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Beesley, J" sort="Beesley, J" uniqKey="Beesley J" first="J" last="Beesley">J. Beesley</name><affiliation wicri:level="1"><nlm:aff id="aff8"><institution>Division of Genetics and Population Health, Queensland Institute of Medical Research</institution> Brisbane,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chen, X" sort="Chen, X" uniqKey="Chen X" first="X" last="Chen">X. Chen</name><affiliation wicri:level="1"><nlm:aff id="aff8"><institution>Division of Genetics and Population Health, Queensland Institute of Medical Research</institution> Brisbane,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Healey, S" sort="Healey, S" uniqKey="Healey S" first="S" last="Healey">S. Healey</name><affiliation wicri:level="1"><nlm:aff id="aff8"><institution>Division of Genetics and Population Health, Queensland Institute of Medical Research</institution> Brisbane,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Neuhausen, S L" sort="Neuhausen, S L" uniqKey="Neuhausen S" first="S L" last="Neuhausen">S L Neuhausen</name><affiliation wicri:level="1"><nlm:aff id="aff10"><institution>Department of Epidemiology, School of Medicine, University of California Irvine</institution> Irvine, CA,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ding, Y C" sort="Ding, Y C" uniqKey="Ding Y" first="Y C" last="Ding">Y C Ding</name><affiliation wicri:level="1"><nlm:aff id="aff10"><institution>Department of Epidemiology, School of Medicine, University of California Irvine</institution> Irvine, CA,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Couch, F J" sort="Couch, F J" uniqKey="Couch F" first="F J" last="Couch">F J Couch</name><affiliation wicri:level="1"><nlm:aff id="aff11"><institution>Department of Laboratory Medicine and Pathology, Mayo Clinic</institution> Rochester, MN,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff12"><institution>Department of Health Sciences Research, Mayo Clinic</institution> Rochester, MN,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wang, X" sort="Wang, X" uniqKey="Wang X" first="X" last="Wang">X. Wang</name><affiliation wicri:level="1"><nlm:aff id="aff11"><institution>Department of Laboratory Medicine and Pathology, Mayo Clinic</institution> Rochester, MN,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lindor, N" sort="Lindor, N" uniqKey="Lindor N" first="N" last="Lindor">N. Lindor</name><affiliation wicri:level="1"><nlm:aff id="aff13"><institution>Department of Medical Genetics, Mayo Clinic</institution> Rochester, MN,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Manoukian, S" sort="Manoukian, S" uniqKey="Manoukian S" first="S" last="Manoukian">S. Manoukian</name><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Fondazione IRCCS Istituto Nazionale Tumori</institution> Milan,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Barile, M" sort="Barile, M" uniqKey="Barile M" first="M" last="Barile">M. Barile</name><affiliation wicri:level="1"><nlm:aff id="aff14"><institution>Istituto Europeo di Oncologia</institution> Milan,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Viel, A" sort="Viel, A" uniqKey="Viel A" first="A" last="Viel">A. Viel</name><affiliation wicri:level="1"><nlm:aff id="aff15"><institution>Centro di Riferimento Oncologico, IRCCS</institution> Aviano, PN,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tizzoni, L" sort="Tizzoni, L" uniqKey="Tizzoni L" first="L" last="Tizzoni">L. Tizzoni</name><affiliation wicri:level="1"><nlm:aff id="aff5"><institution>Fondazione Istituto FIRC di Oncologia Molecolare</institution> Milan,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff16"><institution>Cogentech, Consortium for Genomic Technologies</institution> Milan,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Szabo, C I" sort="Szabo, C I" uniqKey="Szabo C" first="C I" last="Szabo">C I Szabo</name><affiliation wicri:level="1"><nlm:aff id="aff17"><institution>Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine</institution> Rochester, MN,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Foretova, L" sort="Foretova, L" uniqKey="Foretova L" first="L" last="Foretova">L. Foretova</name><affiliation wicri:level="1"><nlm:aff id="aff18"><institution>Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute</institution> Brno,<country>Czech Republic</country></nlm:aff><country xml:lang="fr">République tchèque</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zikan, M" sort="Zikan, M" uniqKey="Zikan M" first="M" last="Zikan">M. Zikan</name><affiliation wicri:level="1"><nlm:aff id="aff19"><institution>Department of Biochemistry and Experimental Oncology, First Faculty of Medicine, Charles University</institution> Prague,<country>Czech Republic</country></nlm:aff><country xml:lang="fr">République tchèque</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Claes, K" sort="Claes, K" uniqKey="Claes K" first="K" last="Claes">K. Claes</name><affiliation wicri:level="1"><nlm:aff id="aff20"><institution>Center for Medical Genetics, Ghent University Hospital</institution> Ghent,<country>Belgium</country></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Greene, M H" sort="Greene, M H" uniqKey="Greene M" first="M H" last="Greene">M H Greene</name><affiliation wicri:level="1"><nlm:aff id="aff21"><institution>Clinical Genetics Branch, National Cancer Institute</institution> Rockville, MD,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mai, P" sort="Mai, P" uniqKey="Mai P" first="P" last="Mai">P. Mai</name><affiliation wicri:level="1"><nlm:aff id="aff21"><institution>Clinical Genetics Branch, National Cancer Institute</institution> Rockville, MD,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rennert, G" sort="Rennert, G" uniqKey="Rennert G" first="G" last="Rennert">G. Rennert</name><affiliation wicri:level="1"><nlm:aff id="aff22"><institution>CHS National Cancer Control Center at Carmel Medical Center and Technion Faculty of Medicine</institution> Haifa,<country>Israel</country></nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lejbkowicz, F" sort="Lejbkowicz, F" uniqKey="Lejbkowicz F" first="F" last="Lejbkowicz">F. Lejbkowicz</name><affiliation wicri:level="1"><nlm:aff id="aff22"><institution>CHS National Cancer Control Center at Carmel Medical Center and Technion Faculty of Medicine</institution> Haifa,<country>Israel</country></nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Barnett Griness, O" sort="Barnett Griness, O" uniqKey="Barnett Griness O" first="O" last="Barnett-Griness">O. Barnett-Griness</name><affiliation wicri:level="1"><nlm:aff id="aff22"><institution>CHS National Cancer Control Center at Carmel Medical Center and Technion Faculty of Medicine</institution> Haifa,<country>Israel</country></nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Andrulis, I L" sort="Andrulis, I L" uniqKey="Andrulis I" first="I L" last="Andrulis">I L Andrulis</name><affiliation><nlm:aff id="aff23"><institution>Ontario Cancer Genetics Network (OCGN), Cancer Care Ontario, Toronto, ON, Canada</institution></nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="aff24"><institution>Fred A. Litwin Center for Cancer Genetics, Samuel Lunenfeld Research Institute</institution> Mount Sinai, Toronto, ON, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea> Mount Sinai, Toronto, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author><author><name sortKey="Ozcelik, H" sort="Ozcelik, H" uniqKey="Ozcelik H" first="H" last="Ozcelik">H. Ozcelik</name><affiliation wicri:level="1"><nlm:aff id="aff24"><institution>Fred A. Litwin Center for Cancer Genetics, Samuel Lunenfeld Research Institute</institution> Mount Sinai, Toronto, ON, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea> Mount Sinai, Toronto, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author><author><name sortKey="Weerasooriya, N" sort="Weerasooriya, N" uniqKey="Weerasooriya N" first="N" last="Weerasooriya">N. Weerasooriya</name><affiliation><nlm:aff id="aff23"><institution>Ontario Cancer Genetics Network (OCGN), Cancer Care Ontario, Toronto, ON, Canada</institution></nlm:aff></affiliation></author><author><name sortKey="Gerdes, A M" sort="Gerdes, A M" uniqKey="Gerdes A" first="A-M" last="Gerdes">A-M Gerdes</name><affiliation wicri:level="1"><nlm:aff id="aff25"><institution>Clinical Genetics BFG, Odense University Hospital</institution> Odense,<country>Denmark</country></nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Thomassen, M" sort="Thomassen, M" uniqKey="Thomassen M" first="M" last="Thomassen">M. Thomassen</name><affiliation wicri:level="1"><nlm:aff id="aff25"><institution>Clinical Genetics BFG, Odense University Hospital</institution> Odense,<country>Denmark</country></nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cruger, D G" sort="Cruger, D G" uniqKey="Cruger D" first="D G" last="Cruger">D G Cruger</name><affiliation wicri:level="1"><nlm:aff id="aff26"><institution>Department of Clinical Genetics, Vejle Hospital</institution><country>Vijle, Denmark</country></nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Caligo, M A" sort="Caligo, M A" uniqKey="Caligo M" first="M A" last="Caligo">M A Caligo</name><affiliation wicri:level="1"><nlm:aff id="aff27"><institution>Division of Pathology, Department of Oncology, University and University Hospital of Pisa</institution> Pisa,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Friedman, E" sort="Friedman, E" uniqKey="Friedman E" first="E" last="Friedman">E. Friedman</name><affiliation><nlm:aff id="aff28"><institution>Sheba Medical Centre (SMC), Tel Hashomer, Israel</institution></nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="aff29"><institution>The Sackler School of Medicine, Tel-Aviv University</institution> Tel-Aviv,<country>Israel</country></nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kaufman, B" sort="Kaufman, B" uniqKey="Kaufman B" first="B" last="Kaufman">B. Kaufman</name><affiliation><nlm:aff id="aff28"><institution>Sheba Medical Centre (SMC), Tel Hashomer, Israel</institution></nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="aff29"><institution>The Sackler School of Medicine, Tel-Aviv University</institution> Tel-Aviv,<country>Israel</country></nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Laitman, Y" sort="Laitman, Y" uniqKey="Laitman Y" first="Y" last="Laitman">Y. Laitman</name><affiliation><nlm:aff id="aff28"><institution>Sheba Medical Centre (SMC), Tel Hashomer, Israel</institution></nlm:aff></affiliation></author><author><name sortKey="Cohen, S" sort="Cohen, S" uniqKey="Cohen S" first="S" last="Cohen">S. Cohen</name><affiliation><nlm:aff id="aff28"><institution>Sheba Medical Centre (SMC), Tel Hashomer, Israel</institution></nlm:aff></affiliation></author><author><name sortKey="Kontorovich, T" sort="Kontorovich, T" uniqKey="Kontorovich T" first="T" last="Kontorovich">T. Kontorovich</name><affiliation><nlm:aff id="aff28"><institution>Sheba Medical Centre (SMC), Tel Hashomer, Israel</institution></nlm:aff></affiliation></author><author><name sortKey="Gershoni Baruch, R" sort="Gershoni Baruch, R" uniqKey="Gershoni Baruch R" first="R" last="Gershoni-Baruch">R. Gershoni-Baruch</name><affiliation wicri:level="1"><nlm:aff id="aff30"><institution>Rambam Medical Centre</institution> Haifa,<country>Israel</country></nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Dagan, E" sort="Dagan, E" uniqKey="Dagan E" first="E" last="Dagan">E. Dagan</name><affiliation wicri:level="1"><nlm:aff id="aff31"><institution>Department of Nursing, Faculty of Social Welfare and Health Sciences, University of Haifa</institution><country>Haifa, Israel</country></nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea></wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff32"><institution>Rambam Health Care Campus, Institute of Human Genetics</institution> Haifa,<country>Israel</country></nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Jernstrom, H" sort="Jernstrom, H" uniqKey="Jernstrom H" first="H" last="Jernström">H. Jernström</name><affiliation wicri:level="1"><nlm:aff id="aff33"><institution>Department of Oncology, Clinical Sciences, Lund University</institution> Lund,<country>Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Askmalm, M S" sort="Askmalm, M S" uniqKey="Askmalm M" first="M S" last="Askmalm">M S Askmalm</name><affiliation wicri:level="1"><nlm:aff id="aff34"><institution>Department of Oncology, University Hospital</institution> Linköping, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea> Linköping</wicri:regionArea></affiliation></author><author><name sortKey="Arver, B" sort="Arver, B" uniqKey="Arver B" first="B" last="Arver">B. Arver</name><affiliation wicri:level="1"><nlm:aff id="aff35"><institution>Department of Oncology, Karolinska University Hospital</institution> Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea> Stockholm</wicri:regionArea></affiliation></author><author><name sortKey="Malmer, B" sort="Malmer, B" uniqKey="Malmer B" first="B" last="Malmer">B. Malmer</name><affiliation wicri:level="1"><nlm:aff id="aff36"><institution>Department of Radiation Sciences, Oncology, Umeå University</institution> Umeå, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea> Umeå</wicri:regionArea></affiliation></author><author><name sortKey="Domchek, S M" sort="Domchek, S M" uniqKey="Domchek S" first="S M" last="Domchek">S M Domchek</name><affiliation><nlm:aff id="aff38"><institution>Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA</institution></nlm:aff></affiliation></author><author><name sortKey="Nathanson, K L" sort="Nathanson, K L" uniqKey="Nathanson K" first="K L" last="Nathanson">K L Nathanson</name><affiliation><nlm:aff id="aff38"><institution>Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA</institution></nlm:aff></affiliation></author><author><name sortKey="Brunet, J" sort="Brunet, J" uniqKey="Brunet J" first="J" last="Brunet">J. Brunet</name><affiliation><nlm:aff id="aff39"><institution>Programa de Consejo Genético en Cáncer, Instituto Catalán de Oncología, Hospital Dr Josep Trueta-IdiBGi, Gerona, Spain</institution></nlm:aff></affiliation></author><author><name sortKey="Ram N Y Cajal, T" sort="Ram N Y Cajal, T" uniqKey="Ram N Y Cajal T" first="T" last="Ram N Y Cajal">T. Ram N Y Cajal</name><affiliation wicri:level="1"><nlm:aff id="aff40"><institution>Servicio de Oncología Médica del Hospital de la Santa Creu i Sant Pau</institution> Barcelona,<country>España</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Yannoukakos, D" sort="Yannoukakos, D" uniqKey="Yannoukakos D" first="D" last="Yannoukakos">D. Yannoukakos</name><affiliation><nlm:aff id="aff41"><institution>IRRP, National Centre for Scientific Research ‘Demokritos', Molecular Diagnostics Laboratory, Athens, Greece</institution></nlm:aff></affiliation></author><author><name sortKey="Hamann, U" sort="Hamann, U" uniqKey="Hamann U" first="U" last="Hamann">U. Hamann</name><affiliation wicri:level="1"><nlm:aff id="aff42"><institution>Molecular Genetics of Breast Cancer, Deutsches Krebsforschungszentrum (DKFZ)</institution> Heidelberg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hogervorst, F B L" sort="Hogervorst, F B L" uniqKey="Hogervorst F" first="F B L" last="Hogervorst">F B L. Hogervorst</name><affiliation wicri:level="1"><nlm:aff id="aff43"><institution>Department of Clinical Molecular Genetics, Family Cancer Clinic, Netherlands Cancer Institute</institution> Amsterdam, NL,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Verhoef, S" sort="Verhoef, S" uniqKey="Verhoef S" first="S" last="Verhoef">S. Verhoef</name><affiliation wicri:level="1"><nlm:aff id="aff43"><institution>Department of Clinical Molecular Genetics, Family Cancer Clinic, Netherlands Cancer Institute</institution> Amsterdam, NL,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Garcia, Eb G Mez" sort="Garcia, Eb G Mez" uniqKey="Garcia E" first="Eb G Mez" last="García">Eb G Mez García</name><affiliation><nlm:aff id="aff44"><institution>Department of Genetics and Cell Biology, University Medical Centre, Maastricht, NL</institution></nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="aff45"><institution>Research Institute Growth and Development (GROW)</institution> Maastricht, NL,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wijnen, J T" sort="Wijnen, J T" uniqKey="Wijnen J" first="J T" last="Wijnen">J T Wijnen</name><affiliation wicri:level="1"><nlm:aff id="aff46"><institution>Department Clinical Molecular Genetics, Leiden University Medical Center</institution> Leiden, NL,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff47"><institution>Department of Human Genetic, Leiden University Medical Center</institution> Leiden, NL,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Van Den Ouweland, A" sort="Van Den Ouweland, A" uniqKey="Van Den Ouweland A" first="A" last="Van Den Ouweland">A. Van Den Ouweland</name><affiliation wicri:level="1"><nlm:aff id="aff48"><institution>Department of Molecular Genetics, Erasmus University Medical Center</institution> Rotterdam, NL,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Easton, D F" sort="Easton, D F" uniqKey="Easton D" first="D F" last="Easton">D F Easton</name><affiliation wicri:level="1"><nlm:aff id="aff49"><institution>Department of Public Health and Primary Care, Cancer Research UK Genetic Epidemiology Unit, University of Cambridge</institution> Cambridge,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Peock, S" sort="Peock, S" uniqKey="Peock S" first="S" last="Peock">S. Peock</name><affiliation wicri:level="1"><nlm:aff id="aff49"><institution>Department of Public Health and Primary Care, Cancer Research UK Genetic Epidemiology Unit, University of Cambridge</institution> Cambridge,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cook, M" sort="Cook, M" uniqKey="Cook M" first="M" last="Cook">M. Cook</name><affiliation wicri:level="1"><nlm:aff id="aff49"><institution>Department of Public Health and Primary Care, Cancer Research UK Genetic Epidemiology Unit, University of Cambridge</institution> Cambridge,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Oliver, C T" sort="Oliver, C T" uniqKey="Oliver C" first="C T" last="Oliver">C T Oliver</name><affiliation wicri:level="1"><nlm:aff id="aff49"><institution>Department of Public Health and Primary Care, Cancer Research UK Genetic Epidemiology Unit, University of Cambridge</institution> Cambridge,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Frost, D" sort="Frost, D" uniqKey="Frost D" first="D" last="Frost">D. Frost</name><affiliation wicri:level="1"><nlm:aff id="aff49"><institution>Department of Public Health and Primary Care, Cancer Research UK Genetic Epidemiology Unit, University of Cambridge</institution> Cambridge,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Luccarini, C" sort="Luccarini, C" uniqKey="Luccarini C" first="C" last="Luccarini">C. Luccarini</name><affiliation wicri:level="1"><nlm:aff id="aff50"><institution>Department of Oncology, University of Cambridge</institution> Cambridge,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Evans, D G" sort="Evans, D G" uniqKey="Evans D" first="D G" last="Evans">D G Evans</name><affiliation wicri:level="1"><nlm:aff id="aff51"><institution>Academic Unit of Medical Genetics and Regional Genetics Service, St Mary's Hospital</institution> Manchester,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lalloo, F" sort="Lalloo, F" uniqKey="Lalloo F" first="F" last="Lalloo">F. Lalloo</name><affiliation wicri:level="1"><nlm:aff id="aff51"><institution>Academic Unit of Medical Genetics and Regional Genetics Service, St Mary's Hospital</institution> Manchester,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Eeles, R" sort="Eeles, R" uniqKey="Eeles R" first="R" last="Eeles">R. Eeles</name><affiliation wicri:level="1"><nlm:aff id="aff52"><institution>Translational Cancer Genetics Team, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust</institution><country>London, UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Pichert, G" sort="Pichert, G" uniqKey="Pichert G" first="G" last="Pichert">G. Pichert</name><affiliation wicri:level="1"><nlm:aff id="aff53"><institution>Clinical Genetics, Guy's Hospital</institution> London,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cook, J" sort="Cook, J" uniqKey="Cook J" first="J" last="Cook">J. Cook</name><affiliation wicri:level="1"><nlm:aff id="aff54"><institution>Sheffield Clinical Genetics Service, Sheffield Children's Hospital</institution> Sheffield,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hodgson, S" sort="Hodgson, S" uniqKey="Hodgson S" first="S" last="Hodgson">S. Hodgson</name><affiliation wicri:level="1"><nlm:aff id="aff55"><institution>Department of Cancer Genetics, St Georges Hospital, University of London</institution> London,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Morrison, P J" sort="Morrison, P J" uniqKey="Morrison P" first="P J" last="Morrison">P J Morrison</name><affiliation wicri:level="1"><nlm:aff id="aff56"><institution>Northern Ireland Regional Genetics Centre, Belfast City Hospital</institution> Belfast,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Douglas, F" sort="Douglas, F" uniqKey="Douglas F" first="F" last="Douglas">F. Douglas</name><affiliation wicri:level="1"><nlm:aff id="aff57"><institution>Institute of Human Genetics, Centre for Life, Newcastle Upon Tyne Hospitals NHS Trust</institution> Newcastle upon Tyne,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Godwin, A K" sort="Godwin, A K" uniqKey="Godwin A" first="A K" last="Godwin">A K Godwin</name><affiliation wicri:level="1"><nlm:aff id="aff58"><institution>Fox Chase Cancer Center</institution> Philadelphia, PA,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sinilnikova, O M" sort="Sinilnikova, O M" uniqKey="Sinilnikova O" first="O M" last="Sinilnikova">O M Sinilnikova</name><affiliation wicri:level="1"><nlm:aff id="aff59"><institution>Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Hospices Civils de Lyon/Centre Léon Bérard</institution> Lyon,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff60"><institution>Laboratoire de Génétique Moléculaire, Signalisation et Cancer, UMR5201 CNRS, Université de Lyon</institution> Lyon,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Barjhoux, L" sort="Barjhoux, L" uniqKey="Barjhoux L" first="L" last="Barjhoux">L. Barjhoux</name><affiliation wicri:level="1"><nlm:aff id="aff59"><institution>Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Hospices Civils de Lyon/Centre Léon Bérard</institution> Lyon,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff60"><institution>Laboratoire de Génétique Moléculaire, Signalisation et Cancer, UMR5201 CNRS, Université de Lyon</institution> Lyon,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Stoppa Lyonnet, D" sort="Stoppa Lyonnet, D" uniqKey="Stoppa Lyonnet D" first="D" last="Stoppa-Lyonnet">D. Stoppa-Lyonnet</name><affiliation wicri:level="1"><nlm:aff id="aff61"><institution>INSERM U509, Service de Génétique Oncologique, Institut Curie, Université Paris-Descartes</institution> Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Moncoutier, V" sort="Moncoutier, V" uniqKey="Moncoutier V" first="V" last="Moncoutier">V. Moncoutier</name><affiliation wicri:level="1"><nlm:aff id="aff61"><institution>INSERM U509, Service de Génétique Oncologique, Institut Curie, Université Paris-Descartes</institution> Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Giraud, S" sort="Giraud, S" uniqKey="Giraud S" first="S" last="Giraud">S. Giraud</name><affiliation wicri:level="1"><nlm:aff id="aff59"><institution>Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Hospices Civils de Lyon/Centre Léon Bérard</institution> Lyon,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cassini, C" sort="Cassini, C" uniqKey="Cassini C" first="C" last="Cassini">C. Cassini</name><affiliation wicri:level="1"><nlm:aff id="aff62"><institution>Centre de Génétique</institution> Dijon,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff63"><institution>CLCC Georges François Leclerc</institution> Dijon,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Olivier Faivre, L" sort="Olivier Faivre, L" uniqKey="Olivier Faivre L" first="L" last="Olivier-Faivre">L. Olivier-Faivre</name><affiliation wicri:level="1"><nlm:aff id="aff62"><institution>Centre de Génétique</institution> Dijon,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff63"><institution>CLCC Georges François Leclerc</institution> Dijon,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Revillion, F" sort="Revillion, F" uniqKey="Revillion F" first="F" last="Révillion">F. Révillion</name><affiliation wicri:level="1"><nlm:aff id="aff64"><institution>Human Molecular Oncology Laboratory, Centre Oscar Lambret</institution> Lille,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Peyrat, J P" sort="Peyrat, J P" uniqKey="Peyrat J" first="J-P" last="Peyrat">J-P Peyrat</name><affiliation wicri:level="1"><nlm:aff id="aff64"><institution>Human Molecular Oncology Laboratory, Centre Oscar Lambret</institution> Lille,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Muller, D" sort="Muller, D" uniqKey="Muller D" first="D" last="Muller">D. Muller</name><affiliation wicri:level="1"><nlm:aff id="aff65"><institution>Unité d'Oncogénétique, CLCC Paul Strauss</institution> Strasbourg,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Fricker, J P" sort="Fricker, J P" uniqKey="Fricker J" first="J-P" last="Fricker">J-P Fricker</name><affiliation wicri:level="1"><nlm:aff id="aff65"><institution>Unité d'Oncogénétique, CLCC Paul Strauss</institution> Strasbourg,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lynch, H T" sort="Lynch, H T" uniqKey="Lynch H" first="H T" last="Lynch">H T Lynch</name><affiliation wicri:level="1"><nlm:aff id="aff66"><institution>Department of Preventive Medicine, Creighton University</institution> Omaha, NE,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="John, E M" sort="John, E M" uniqKey="John E" first="E M" last="John">E M John</name><affiliation wicri:level="1"><nlm:aff id="aff67"><institution>Northern California Cancer Center</institution> Fremont, CA,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Buys, S" sort="Buys, S" uniqKey="Buys S" first="S" last="Buys">S. Buys</name><affiliation wicri:level="1"><nlm:aff id="aff68"><institution>Huntsman Cancer Institute</institution> Salt Lake City, UT,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Daly, M" sort="Daly, M" uniqKey="Daly M" first="M" last="Daly">M. Daly</name><affiliation wicri:level="1"><nlm:aff id="aff69"><institution>Fox Chase Cancer Center</institution> Philadelphia, PA,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hopper, J L" sort="Hopper, J L" uniqKey="Hopper J" first="J L" last="Hopper">J L Hopper</name><affiliation wicri:level="1"><nlm:aff id="aff70"><institution>University of Melbourne</institution> Melbourne,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Terry, M B" sort="Terry, M B" uniqKey="Terry M" first="M B" last="Terry">M B Terry</name><affiliation wicri:level="1"><nlm:aff id="aff71"><institution>Columbia University New York</institution> NY,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Miron, A" sort="Miron, A" uniqKey="Miron A" first="A" last="Miron">A. Miron</name><affiliation wicri:level="1"><nlm:aff id="aff72"><institution>Dana Farber Cancer Institute</institution> Boston, MA,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Yassin, Y" sort="Yassin, Y" uniqKey="Yassin Y" first="Y" last="Yassin">Y. Yassin</name><affiliation wicri:level="1"><nlm:aff id="aff72"><institution>Dana Farber Cancer Institute</institution> Boston, MA,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Goldgar, D" sort="Goldgar, D" uniqKey="Goldgar D" first="D" last="Goldgar">D. Goldgar</name><affiliation wicri:level="1"><nlm:aff id="aff73"><institution>Department of Dermatology, University of Utah</institution> Salt Lake City, UT,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Singer, C F" sort="Singer, C F" uniqKey="Singer C" first="C F" last="Singer">C F Singer</name><affiliation wicri:level="1"><nlm:aff id="aff74"><institution>Division of Special Gynecology, Department of OB/GYN, Medical University of Vienna</institution> Vienna,<country>Austria</country></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gschwantler Kaulich, D" sort="Gschwantler Kaulich, D" uniqKey="Gschwantler Kaulich D" first="D" last="Gschwantler-Kaulich">D. Gschwantler-Kaulich</name><affiliation wicri:level="1"><nlm:aff id="aff74"><institution>Division of Special Gynecology, Department of OB/GYN, Medical University of Vienna</institution> Vienna,<country>Austria</country></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Pfeiler, G" sort="Pfeiler, G" uniqKey="Pfeiler G" first="G" last="Pfeiler">G. Pfeiler</name><affiliation wicri:level="1"><nlm:aff id="aff74"><institution>Division of Special Gynecology, Department of OB/GYN, Medical University of Vienna</institution> Vienna,<country>Austria</country></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Spiess, A C" sort="Spiess, A C" uniqKey="Spiess A" first="A-C" last="Spiess">A-C Spiess</name><affiliation wicri:level="1"><nlm:aff id="aff74"><institution>Division of Special Gynecology, Department of OB/GYN, Medical University of Vienna</institution> Vienna,<country>Austria</country></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hansen, Thomas V O" sort="Hansen, Thomas V O" uniqKey="Hansen T" first="Thomas V O" last="Hansen">Thomas V O. Hansen</name><affiliation wicri:level="1"><nlm:aff id="aff75"><institution>Department of Biochemistry, Pharmacology, and Genetics, Odense University Hospital</institution><country>Odense, Denmark</country></nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Johannsson, O T" sort="Johannsson, O T" uniqKey="Johannsson O" first="O T" last="Johannsson">O T Johannsson</name><affiliation wicri:level="1"><nlm:aff id="aff76"><institution>Department of Oncology, Landspitali-University Hospital</institution> Reykjavik,<country>Iceland</country> (OThJ)</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kirchhoff, T" sort="Kirchhoff, T" uniqKey="Kirchhoff T" first="T" last="Kirchhoff">T. Kirchhoff</name><affiliation wicri:level="1"><nlm:aff id="aff77"><institution>Department of Medicine, Clinical Genetics Service, Memorial Sloan-Kettering Cancer Center</institution> New York, NY,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Offit, K" sort="Offit, K" uniqKey="Offit K" first="K" last="Offit">K. Offit</name><affiliation wicri:level="1"><nlm:aff id="aff77"><institution>Department of Medicine, Clinical Genetics Service, Memorial Sloan-Kettering Cancer Center</institution> New York, NY,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kosarin, K" sort="Kosarin, K" uniqKey="Kosarin K" first="K" last="Kosarin">K. Kosarin</name><affiliation wicri:level="1"><nlm:aff id="aff77"><institution>Department of Medicine, Clinical Genetics Service, Memorial Sloan-Kettering Cancer Center</institution> New York, NY,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Piedmonte, M" sort="Piedmonte, M" uniqKey="Piedmonte M" first="M" last="Piedmonte">M. Piedmonte</name><affiliation wicri:level="1"><nlm:aff id="aff78"><institution>GOG Statistical and Data Center, Roswell Park Cancer Institute</institution> Buffalo, NY,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rodriguez, G C" sort="Rodriguez, G C" uniqKey="Rodriguez G" first="G C" last="Rodriguez">G C Rodriguez</name><affiliation wicri:level="1"><nlm:aff id="aff79"><institution>NorthShore University Health System, Evanston Northwestern Healthcare</institution> Evanston, IL,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wakeley, K" sort="Wakeley, K" uniqKey="Wakeley K" first="K" last="Wakeley">K. Wakeley</name><affiliation wicri:level="1"><nlm:aff id="aff80"><institution>Tufts University, New England Medical Center</institution> Boston, MA,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Boggess, J F" sort="Boggess, J F" uniqKey="Boggess J" first="J F" last="Boggess">J F Boggess</name><affiliation wicri:level="1"><nlm:aff id="aff81"><institution>University of North Carolina</institution> Chapel Hill, NC,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Basil, J" sort="Basil, J" uniqKey="Basil J" first="J" last="Basil">J. Basil</name><affiliation wicri:level="1"><nlm:aff id="aff82"><institution>St Elizabeth Medical Center</institution> Edgewood, KY,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Schwartz, P E" sort="Schwartz, P E" uniqKey="Schwartz P" first="P E" last="Schwartz">P E Schwartz</name><affiliation wicri:level="1"><nlm:aff id="aff83"><institution>Yale University School of Medicine</institution> New Haven, CT,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Blank, S V" sort="Blank, S V" uniqKey="Blank S" first="S V" last="Blank">S V Blank</name><affiliation wicri:level="1"><nlm:aff id="aff84"><institution>New York University School of Medicine</institution> New York, NY,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Toland, A E" sort="Toland, A E" uniqKey="Toland A" first="A E" last="Toland">A E Toland</name><affiliation><nlm:aff id="aff85"><institution>Division of Human Cancer Genetics, Departments of Internal Medicine and Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, OHIO, USA</institution></nlm:aff></affiliation></author><author><name sortKey="Montagna, M" sort="Montagna, M" uniqKey="Montagna M" first="M" last="Montagna">M. Montagna</name><affiliation wicri:level="1"><nlm:aff id="aff86"><institution>Instituto Oncologico Veneto – IRCCS</institution> Padua,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Casella, C" sort="Casella, C" uniqKey="Casella C" first="C" last="Casella">C. Casella</name><affiliation wicri:level="1"><nlm:aff id="aff87"><institution>Department of Oncology and Surgical Sciences</institution> Padua,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Imyanitov, E N" sort="Imyanitov, E N" uniqKey="Imyanitov E" first="E N" last="Imyanitov">E N Imyanitov</name><affiliation wicri:level="1"><nlm:aff id="aff88"><institution>N.N. Petrov Institute of Oncology</institution> St-Petersburg,<country>Russia</country></nlm:aff><country xml:lang="fr">Russie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Allavena, A" sort="Allavena, A" uniqKey="Allavena A" first="A" last="Allavena">A. Allavena</name><affiliation wicri:level="1"><nlm:aff id="aff89"><institution>Department of Genetics, Biology and Biochemistry, University of Turin</institution> Turin,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Schmutzler, R K" sort="Schmutzler, R K" uniqKey="Schmutzler R" first="R K" last="Schmutzler">R K Schmutzler</name><affiliation wicri:level="1"><nlm:aff id="aff90"><institution>Division of Molecular Gynaeco-Oncology, Department of Obstetrics and Gynaecology, University of Cologne</institution><country>Cologne, Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Versmold, B" sort="Versmold, B" uniqKey="Versmold B" first="B" last="Versmold">B. Versmold</name><affiliation wicri:level="1"><nlm:aff id="aff90"><institution>Division of Molecular Gynaeco-Oncology, Department of Obstetrics and Gynaecology, University of Cologne</institution><country>Cologne, Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Engel, C" sort="Engel, C" uniqKey="Engel C" first="C" last="Engel">C. Engel</name><affiliation wicri:level="1"><nlm:aff id="aff91"><institution>Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig</institution><country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Meindl, A" sort="Meindl, A" uniqKey="Meindl A" first="A" last="Meindl">A. Meindl</name><affiliation wicri:level="1"><nlm:aff id="aff92"><institution>Department of Obstetrics and Gynaecology, Technical University Munich</institution><country>Munich, Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Ditsch, N" sort="Ditsch, N" uniqKey="Ditsch N" first="N" last="Ditsch">N. Ditsch</name><affiliation wicri:level="1"><nlm:aff id="aff93"><institution>Department of Obstetrics and Gynaecology, Ludwig-Maximilian University Munich</institution> Munich,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Arnold, N" sort="Arnold, N" uniqKey="Arnold N" first="N" last="Arnold">N. Arnold</name><affiliation wicri:level="1"><nlm:aff id="aff94"><institution>Department of Obstetrics and Gynaecology, University of Schleswig-Holstein</institution> Campus Kiel,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Niederacher, D" sort="Niederacher, D" uniqKey="Niederacher D" first="D" last="Niederacher">D. Niederacher</name><affiliation wicri:level="1"><nlm:aff id="aff95"><institution>Department of Obstetrics and Gynaecology, Molecular Genetics Laboratory, University of Duesseldorf</institution><country>Dusseldorf, Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Dei Ler, H" sort="Dei Ler, H" uniqKey="Dei Ler H" first="H" last="Dei Ler">H. Dei Ler</name><affiliation wicri:level="1"><nlm:aff id="aff96"><institution>Department of Obstetrics and Gynaecology, University of Ulm</institution> Ulm,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Fiebig, B" sort="Fiebig, B" uniqKey="Fiebig B" first="B" last="Fiebig">B. Fiebig</name><affiliation wicri:level="1"><nlm:aff id="aff97"><institution>University of Regensburg, Institute of Human Genetics</institution> Regensburg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Varon Mateeva, R" sort="Varon Mateeva, R" uniqKey="Varon Mateeva R" first="R" last="Varon-Mateeva">R. Varon-Mateeva</name><affiliation wicri:level="1"><nlm:aff id="aff98"><institution>Institute of Human Genetics, Charité, Humboldt University</institution> Berlin,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Schaefer, D" sort="Schaefer, D" uniqKey="Schaefer D" first="D" last="Schaefer">D. Schaefer</name><affiliation wicri:level="1"><nlm:aff id="aff99"><institution>Institute of Human Genetics, University of Frankfurt</institution> Frankfurt,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Froster, U G" sort="Froster, U G" uniqKey="Froster U" first="U G" last="Froster">U G Froster</name><affiliation wicri:level="1"><nlm:aff id="aff100"><institution>Institute of Human Genetics, University of Leipzig</institution> Leipzig,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Caldes, T" sort="Caldes, T" uniqKey="Caldes T" first="T" last="Caldes">T. Caldes</name><affiliation wicri:level="1"><nlm:aff id="aff101"><institution>Hospital Clínico San Carlos</institution> Madrid,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="De La Hoya, M" sort="De La Hoya, M" uniqKey="De La Hoya M" first="M" last="De La Hoya">M. De La Hoya</name><affiliation wicri:level="1"><nlm:aff id="aff101"><institution>Hospital Clínico San Carlos</institution> Madrid,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mcguffog, L" sort="Mcguffog, L" uniqKey="Mcguffog L" first="L" last="Mcguffog">L. Mcguffog</name><affiliation wicri:level="1"><nlm:aff id="aff49"><institution>Department of Public Health and Primary Care, Cancer Research UK Genetic Epidemiology Unit, University of Cambridge</institution> Cambridge,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Antoniou, A C" sort="Antoniou, A C" uniqKey="Antoniou A" first="A C" last="Antoniou">A C Antoniou</name><affiliation wicri:level="1"><nlm:aff id="aff49"><institution>Department of Public Health and Primary Care, Cancer Research UK Genetic Epidemiology Unit, University of Cambridge</institution> Cambridge,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Nevanlinna, H" sort="Nevanlinna, H" uniqKey="Nevanlinna H" first="H" last="Nevanlinna">H. Nevanlinna</name><affiliation wicri:level="1"><nlm:aff id="aff6"><institution>Department of Obstetrics and Gynaecology, Helsinki University Central Hospital (HUCH)</institution> HelsVinki,<country>Finland</country></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Radice, P" sort="Radice, P" uniqKey="Radice P" first="P" last="Radice">P. Radice</name><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Fondazione IRCCS Istituto Nazionale Tumori</institution> Milan,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff5"><institution>Fondazione Istituto FIRC di Oncologia Molecolare</institution> Milan,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Benitez, J" sort="Benitez, J" uniqKey="Benitez J" first="J" last="Benítez">J. Benítez</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Human Genetics Group, Spanish National Cancer Research Centre</institution> Madrid,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Genotyping Unit, Human Cancer Genetics Programme, Spanish National Cancer Research Centre</institution> Madrid,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">British Journal of Cancer</title><idno type="ISSN">0007-0920</idno><idno type="eISSN">1532-1827</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background:</title><p>In this study we aimed to evaluate the role of a SNP in intron 1 of the <italic>ERCC4</italic> gene (rs744154), previously reported to be associated with a reduced risk of breast cancer in the general population, as a breast cancer risk modifier in <italic>BRCA1</italic> and <italic>BRCA2</italic> mutation carriers.</p></sec><sec><title>Methods:</title><p>We have genotyped rs744154 in 9408 <italic>BRCA1</italic> and 5632 <italic>BRCA2</italic> mutation carriers from the Consortium of Investigators of Modifiers of <italic>BRCA1/2</italic> (CIMBA) and assessed its association with breast cancer risk using a retrospective weighted cohort approach.</p></sec><sec><title>Results:</title><p>We found no evidence of association with breast cancer risk for <italic>BRCA1</italic> (per-allele HR: 0.98, 95% CI: 0.93–1.04, <italic>P</italic>=0.5) or <italic>BRCA2</italic> (per-allele HR: 0.97, 95% CI: 0.89–1.06, <italic>P</italic>=0.5) mutation carriers.</p></sec><sec><title>Conclusion:</title><p>This SNP is not a significant modifier of breast cancer risk for mutation carriers, though weak associations cannot be ruled out.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Autriche</li><li>Belgique</li><li>Canada</li><li>Danemark</li><li>Espagne</li><li>Finlande</li><li>France</li><li>Islande</li><li>Israël</li><li>Italie</li><li>Royaume-Uni</li><li>Russie</li><li>République tchèque</li><li>Suède</li><li>États-Unis</li></country></list><tree><noCountry><name sortKey="Brunet, J" sort="Brunet, J" uniqKey="Brunet J" first="J" last="Brunet">J. Brunet</name><name sortKey="Cohen, S" sort="Cohen, S" uniqKey="Cohen S" first="S" last="Cohen">S. Cohen</name><name sortKey="Domchek, S M" sort="Domchek, S M" uniqKey="Domchek S" first="S M" last="Domchek">S M Domchek</name><name sortKey="Kontorovich, T" sort="Kontorovich, T" uniqKey="Kontorovich T" first="T" last="Kontorovich">T. Kontorovich</name><name sortKey="Laitman, Y" sort="Laitman, Y" uniqKey="Laitman Y" first="Y" last="Laitman">Y. Laitman</name><name sortKey="Nathanson, K L" sort="Nathanson, K L" uniqKey="Nathanson K" first="K L" last="Nathanson">K L Nathanson</name><name sortKey="Simard, J" sort="Simard, J" uniqKey="Simard J" first="J" last="Simard">J. Simard</name><name sortKey="Toland, A E" sort="Toland, A E" uniqKey="Toland A" first="A E" last="Toland">A E Toland</name><name sortKey="Weerasooriya, N" sort="Weerasooriya, N" uniqKey="Weerasooriya N" first="N" last="Weerasooriya">N. Weerasooriya</name><name sortKey="Yannoukakos, D" sort="Yannoukakos, D" uniqKey="Yannoukakos D" first="D" last="Yannoukakos">D. Yannoukakos</name></noCountry><country name="Espagne"><noRegion><name sortKey="Osorio, A" sort="Osorio, A" uniqKey="Osorio A" first="A" last="Osorio">A. Osorio</name></noRegion><name sortKey="Benitez, J" sort="Benitez, J" uniqKey="Benitez J" first="J" last="Benítez">J. Benítez</name><name sortKey="Benitez, J" sort="Benitez, J" uniqKey="Benitez J" first="J" last="Benítez">J. Benítez</name><name sortKey="Caldes, T" sort="Caldes, T" uniqKey="Caldes T" first="T" last="Caldes">T. Caldes</name><name sortKey="De La Hoya, M" sort="De La Hoya, M" uniqKey="De La Hoya M" first="M" last="De La Hoya">M. De La Hoya</name><name sortKey="Milne, R L" sort="Milne, R L" uniqKey="Milne R" first="R L" last="Milne">R L Milne</name><name sortKey="Pita, G" sort="Pita, G" uniqKey="Pita G" first="G" last="Pita">G. Pita</name><name sortKey="Ram N Y Cajal, T" sort="Ram N Y Cajal, T" uniqKey="Ram N Y Cajal T" first="T" last="Ram N Y Cajal">T. Ram N Y Cajal</name></country><country name="Italie"><noRegion><name sortKey="Peterlongo, P" sort="Peterlongo, P" uniqKey="Peterlongo P" first="P" last="Peterlongo">P. Peterlongo</name></noRegion><name sortKey="Allavena, A" sort="Allavena, A" uniqKey="Allavena A" first="A" last="Allavena">A. Allavena</name><name sortKey="Barile, M" sort="Barile, M" uniqKey="Barile M" first="M" last="Barile">M. Barile</name><name sortKey="Caligo, M A" sort="Caligo, M A" uniqKey="Caligo M" first="M A" last="Caligo">M A Caligo</name><name sortKey="Casella, C" sort="Casella, C" uniqKey="Casella C" first="C" last="Casella">C. Casella</name><name sortKey="Manoukian, S" sort="Manoukian, S" uniqKey="Manoukian S" first="S" last="Manoukian">S. Manoukian</name><name sortKey="Montagna, M" sort="Montagna, M" uniqKey="Montagna M" first="M" last="Montagna">M. Montagna</name><name sortKey="Peterlongo, P" sort="Peterlongo, P" uniqKey="Peterlongo P" first="P" last="Peterlongo">P. Peterlongo</name><name sortKey="Radice, P" sort="Radice, P" uniqKey="Radice P" first="P" last="Radice">P. Radice</name><name sortKey="Radice, P" sort="Radice, P" uniqKey="Radice P" first="P" last="Radice">P. Radice</name><name sortKey="Tizzoni, L" sort="Tizzoni, L" uniqKey="Tizzoni L" first="L" last="Tizzoni">L. Tizzoni</name><name sortKey="Tizzoni, L" sort="Tizzoni, L" uniqKey="Tizzoni L" first="L" last="Tizzoni">L. Tizzoni</name><name sortKey="Viel, A" sort="Viel, A" uniqKey="Viel A" first="A" last="Viel">A. Viel</name></country><country name="Finlande"><noRegion><name sortKey="Heikkinen, T" sort="Heikkinen, T" uniqKey="Heikkinen T" first="T" last="Heikkinen">T. Heikkinen</name></noRegion><name sortKey="Nevanlinna, H" sort="Nevanlinna, H" uniqKey="Nevanlinna H" first="H" last="Nevanlinna">H. Nevanlinna</name></country><country name="Australie"><noRegion><name sortKey="Chenevix Trench, G" sort="Chenevix Trench, G" uniqKey="Chenevix Trench G" first="G" last="Chenevix-Trench">G. Chenevix-Trench</name></noRegion><name sortKey="Beesley, J" sort="Beesley, J" uniqKey="Beesley J" first="J" last="Beesley">J. Beesley</name><name sortKey="Chen, X" sort="Chen, X" uniqKey="Chen X" first="X" last="Chen">X. Chen</name><name sortKey="Healey, S" sort="Healey, S" uniqKey="Healey S" first="S" last="Healey">S. Healey</name><name sortKey="Hopper, J L" sort="Hopper, J L" uniqKey="Hopper J" first="J L" last="Hopper">J L Hopper</name><name sortKey="Spurdle, A B" sort="Spurdle, A B" uniqKey="Spurdle A" first="A B" last="Spurdle">A B Spurdle</name></country><country name="États-Unis"><noRegion><name sortKey="Neuhausen, S L" sort="Neuhausen, S L" uniqKey="Neuhausen S" first="S L" last="Neuhausen">S L Neuhausen</name></noRegion><name sortKey="Basil, J" sort="Basil, J" uniqKey="Basil J" first="J" last="Basil">J. Basil</name><name sortKey="Blank, S V" sort="Blank, S V" uniqKey="Blank S" first="S V" last="Blank">S V Blank</name><name sortKey="Boggess, J F" sort="Boggess, J F" uniqKey="Boggess J" first="J F" last="Boggess">J F Boggess</name><name sortKey="Buys, S" sort="Buys, S" uniqKey="Buys S" first="S" last="Buys">S. Buys</name><name sortKey="Couch, F J" sort="Couch, F J" uniqKey="Couch F" first="F J" last="Couch">F J Couch</name><name sortKey="Couch, F J" sort="Couch, F J" uniqKey="Couch F" first="F J" last="Couch">F J Couch</name><name sortKey="Daly, M" sort="Daly, M" uniqKey="Daly M" first="M" last="Daly">M. Daly</name><name sortKey="Ding, Y C" sort="Ding, Y C" uniqKey="Ding Y" first="Y C" last="Ding">Y C Ding</name><name sortKey="Garcia, Eb G Mez" sort="Garcia, Eb G Mez" uniqKey="Garcia E" first="Eb G Mez" last="García">Eb G Mez García</name><name sortKey="Godwin, A K" sort="Godwin, A K" uniqKey="Godwin A" first="A K" last="Godwin">A K Godwin</name><name sortKey="Goldgar, D" sort="Goldgar, D" uniqKey="Goldgar D" first="D" last="Goldgar">D. Goldgar</name><name sortKey="Greene, M H" sort="Greene, M H" uniqKey="Greene M" first="M H" last="Greene">M H Greene</name><name sortKey="Hogervorst, F B L" sort="Hogervorst, F B L" uniqKey="Hogervorst F" first="F B L" last="Hogervorst">F B L. Hogervorst</name><name sortKey="John, E M" sort="John, E M" uniqKey="John E" first="E M" last="John">E M John</name><name sortKey="Kirchhoff, T" sort="Kirchhoff, T" uniqKey="Kirchhoff T" first="T" last="Kirchhoff">T. Kirchhoff</name><name sortKey="Kosarin, K" sort="Kosarin, K" uniqKey="Kosarin K" first="K" last="Kosarin">K. Kosarin</name><name sortKey="Lindor, N" sort="Lindor, N" uniqKey="Lindor N" first="N" last="Lindor">N. Lindor</name><name sortKey="Lynch, H T" sort="Lynch, H T" uniqKey="Lynch H" first="H T" last="Lynch">H T Lynch</name><name sortKey="Mai, P" sort="Mai, P" uniqKey="Mai P" first="P" last="Mai">P. Mai</name><name sortKey="Miron, A" sort="Miron, A" uniqKey="Miron A" first="A" last="Miron">A. Miron</name><name sortKey="Offit, K" sort="Offit, K" uniqKey="Offit K" first="K" last="Offit">K. Offit</name><name sortKey="Piedmonte, M" sort="Piedmonte, M" uniqKey="Piedmonte M" first="M" last="Piedmonte">M. 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Stoppa-Lyonnet</name></country><country name="Autriche"><noRegion><name sortKey="Singer, C F" sort="Singer, C F" uniqKey="Singer C" first="C F" last="Singer">C F Singer</name></noRegion><name sortKey="Gschwantler Kaulich, D" sort="Gschwantler Kaulich, D" uniqKey="Gschwantler Kaulich D" first="D" last="Gschwantler-Kaulich">D. Gschwantler-Kaulich</name><name sortKey="Pfeiler, G" sort="Pfeiler, G" uniqKey="Pfeiler G" first="G" last="Pfeiler">G. Pfeiler</name><name sortKey="Spiess, A C" sort="Spiess, A C" uniqKey="Spiess A" first="A-C" last="Spiess">A-C Spiess</name></country><country name="Islande"><noRegion><name sortKey="Johannsson, O T" sort="Johannsson, O T" uniqKey="Johannsson O" first="O T" last="Johannsson">O T Johannsson</name></noRegion></country><country name="Russie"><noRegion><name sortKey="Imyanitov, E N" sort="Imyanitov, E N" uniqKey="Imyanitov E" first="E N" last="Imyanitov">E N Imyanitov</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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